Jingxin Fu

This study identifies a loss of osteoblastic lineage fidelity in metastatic osteosarcoma through single-nucleus RNA sequencing, linking it to disease progression and potential therapeutic targets.

This study evaluates agentic AI's ability to support biological discovery in autonomous and human-AI copilot settings using multi-omic cancer datasets.

This study identifies epigenetic dysregulation of metabolic programs in liposarcoma, linking IGF1 loss and PPARG2 deficiency to dedifferentiation and proposing IGF1R-targeted therapy.

This study shows that the filamentous fungus Thermothelomyces heterothallica C1 can produce thermostable SARS-CoV-2 spike protein with a human-like glycan profile, comparable to mammalian systems.

The paper identifies distinct immune and stromal features in HR+ HER2-low and HER2-0 breast cancers using molecular and multiplexed imaging.

The paper introduces BEANIE, a nonparametric method to improve differential enrichment analysis in single-cell transcriptomics by accounting for sample-specific biology and robustness of signatures across cohorts.