The C99 domain of the amyloid precursor protein is a disordered membrane phase-preferring protein
Ricardo F. Capone, Ajit Tiwari, Arina Hadziselimovic, Yelena B. Peskova, James M. Hutchison, Charles R. Sanders, Anne K. Kenworthy
The paper investigates the membrane association of C99, finding it preferentially localizes to disordered domains rather than raft domains, challenging previous assumptions about its role in amyloidogenic processing.
Journal of Biological Chemistry · Jan 1, 2021Peer-reviewedNeuroscience