Charles R. Sanders

The paper identifies small-molecule modulators of lipid raft stability and protein-raft partitioning, revealing two classes of compounds with distinct mechanisms of action.

The paper develops classifiers to distinguish functional and trafficking effects of KCNQ1 variants, improving variant interpretation for LQTS and channelopathies.

This study identifies a small molecule, VU0494372, that enhances KCNQ1 expression and trafficking, offering a potential therapeutic approach for LQTS.

The paper develops a synthetic antibody fragment that binds to 10 claudin subtypes, opening tight junctions and modulating paracellular permeability.

The paper investigates the membrane association of C99, finding it preferentially localizes to disordered domains rather than raft domains, challenging previous assumptions about its role in amyloidogenic processing.

The paper assesses how well existing human protein 3D structures represent genetic and functional diversity across the 1000 Genomes Project, finding significant underrepresentation of African ancestry sequences.

The paper uses live cell imaging to show that APP and synaptic membrane cholesterol levels reciprocally modulate at synaptic boutons.

This study evaluates KCNQ1 variants using high-throughput electrophysiology, classifying 70% of unstudied variants and showing allele frequency is not a reliable predictor of function.