ClC-2 contributes to hypotonicity-induced adrenal aldosterone secretion
Marina Volkert, Hoang An Dinh, Ute I. Scholl, Gabriel Stölting
This study shows that ClC-2 chloride channels in adrenal zona glomerulosa cells mediate hypoosmotic stress responses by enabling chloride efflux, depolarization, and calcium influx, which drive aldosterone production.
Acta Physiologica · Jan 28, 2026Peer-reviewedPhysiology