High-efficiency Kemp eliminases by complete computational design
Dina Listov, Eva Vos, Gyula Hoffka, Shlomo Yakir Hoch, Andrej Berg, Shelly Hamer-Rogotner, Orly Dym, Shina Caroline Lynn Kamerlin, Sarel Jacob Fleishman
This paper presents a computational design of high-efficiency Kemp eliminases with unprecedented catalytic efficiency and stability through de novo enzyme design.
Nature · Jun 18, 2025Peer-reviewedBiochemistry