Orly Dym

Systematic DNA nicking reveals the structural logic of protein recognition

This study introduces PIC-NIC, a method to systematically perturb DNA binding sites without altering base sequences, revealing how DNA backbone structure influences transcription factor binding.

High-efficiency Kemp eliminases by complete computational design

This paper presents a computational design of high-efficiency Kemp eliminases with unprecedented catalytic efficiency and stability through de novo enzyme design.

An unconventional interaction interface between the peroxisomal targeting factor Pex5 and Eci1 enables PTS1 independent import

The paper identifies an unconventional Pex5-Eci1 interaction interface that enables PTS1-independent peroxisomal import of Eci1 in yeast.

Cathepsin X is a conserved cell death protein involved in algal response to environmental stress

The paper identifies cathepsin X as a conserved cell death protein in algae involved in responses to environmental stress through transcriptome analysis and mutant studies.