BioinformaticsNature BiotechnologyPeer-reviewed
Scoring gene importance by interpreting single-cell foundation models
Maxwell P. Gold, Miguel Reyes, Nathaniel Diamant…·Tommaso Biancalani
The paper introduces SIGnature, a framework for scoring gene importance using attributions from scRNA-seq foundation models, and demonstrates its utility in identifying novel associations of the MS1 signature with hyperinflammatory conditions.