Scoring gene importance by interpreting single-cell foundation models
Maxwell P. Gold, Miguel Reyes, Nathaniel Diamant, Tony Chien-Yen Kuo, Ehsan Hajiramezanali, Jane W. Newburger, Mary Beth F. Son, Pui Y. Lee, Gabriele Scalia, Aïcha BenTaieb, Sharookh B. Kapadia, Anupriya Tripathi, Héctor Corrada Bravo, Graham Heimberg, Tommaso Biancalani
The paper introduces SIGnature, a framework for scoring gene importance using attributions from scRNA-seq foundation models, and demonstrates its utility in identifying novel associations of the MS1 signature with hyperinflammatory conditions.
Nature Biotechnology · May 27, 2026Peer-reviewedBioinformatics