Miguel Reyes

The paper introduces SIGnature, a framework for scoring gene importance using attributions from scRNA-seq foundation models, and demonstrates its utility in identifying novel associations of the MS1 signature with hyperinflammatory conditions.

This study identifies G-CSF and IL-6 as drivers of myeloid dysregulation during severe viral infection, showing their role in emergency myelopoiesis and tissue injury.

The paper uses plasma proteomics to identify tissue-specific cell death and cell-cell interaction mediators in severe COVID-19 patients, linking them to survival outcomes and viral infection effects.