Author

Adam C. Mater

Australian National UniversityORCID 0000-0002-7395-4337Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Assay:protein sequence· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Research Focus:sequence-to-function modeling· 1

Frequent Co-Authors

Colin J. JacksoniD· 2 shared Dana S. MatthewsiD· 2 shared Mahakaran Sandhu· 2 shared Matthew A. SpenceiD· 2 shared Artem A. LenskiyiD· 1 shared Charlotte M. MitoniD· 1 shared James NicholsiD· 1 shared Joe A. KaczmarskiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersSynthetic Biology

Colin J. JacksonORCID

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2 papers

Recent·Most cited

Investigating the determinants of performance in machine learning for protein fitness prediction

Mahakaran Sandhu, Adam C. Mater, Dana S. Matthews, Matthew A. Spence, Artem A. Lenskiy, Colin J. Jackson

This study evaluates ML architectures for protein fitness prediction using simulated and empirical landscapes, identifying landscape ruggedness as a key determinant of accuracy.

Protein Science · Jul 21, 2025Peer-reviewedSynthetic Biology

Leveraging ancestral sequence reconstruction for protein representation learning

Dana S. Matthews, Matthew A. Spence, Adam C. Mater, James Nichols, Sacha B. Pulsford, Mahakaran Sandhu, Joe A. Kaczmarski, Charlotte M. Miton, Nobuhiko Tokuriki, Colin J. Jackson

This paper introduces LASE, a method using ancestral sequence reconstruction to train protein language models with higher accuracy and faster computation than large models.

Nature Machine Intelligence · Dec 18, 2024Peer-reviewedBioinformatics