Systems BiologybioRxivPreprint
Biphasic Temporal Remodeling Of The Proteome In A Polyglutamine-Expanded Huntingtin In Vitro Aggregation Cell Model: From Early Rna-Regulatory Compensation To Selective Mitochondrial Energy Failure
Ekin Sönmez, Pınar Mutlu, Cinla Ozlevent…·Hüseyin Çimen
This study identifies a biphasic proteomic remodeling in a Huntington's disease cell model, showing early RNA regulatory compensation and late mitochondrial failure, with potential drug targets identified.
DOI 10.64898/2026.08.21.746221