Ergosterol acts as a permissive regulator of Ire1 responsiveness during ER stress
Lucía Porrini, Juan Cruz Almada, Ana Bortolotti, Antonio D. Uttaro, Germán L. Rosano, Larisa E. Cybulski
This study shows ergosterol modulates Ire1 activation during ER stress by adjusting UPR response amplitude, not directly triggering the pathway.
bioRxiv · Jun 22, 2026 · PreprintCell Biology