Author

Robert Edward Thorne

Cornell UniversityORCID 0000-0002-7489-8074Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Matthew J. McLeodiD· 2 shared Sarah A. E. BarwelliD· 1 shared Todd HolyoakiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersBiophysics

Matthew J. McLeodORCID

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2 papers

Recent·Most cited

Activation parameters, enthalpy-entropy compensation and the temperature-dependent activity of enzymes

Matthew J. McLeod, Robert Edward Thorne

The paper examines how small temperature variations in enzyme activation parameters affect Arrhenius/Eyring modeling, leading to apparent enthalpy-entropy compensation and misinterpretation of kinetic data.

Protein Science · Jul 24, 2026Peer-reviewedBiophysics

A structural perspective on the temperature-dependent activity of enzymes

Matthew J. McLeod, Sarah A. E. Barwell, Todd Holyoak, Robert Edward Thorne

The paper uses multi-temperature X-ray crystallography to show how temperature-dependent structural changes in enzyme complexes affect activity and challenge assumptions of Arrhenius/Eyring model parameters.

Structure · Mar 22, 2025Peer-reviewedBiophysics