Author

Sarah A. E. Barwell

University of WaterlooORCID 0000-0002-5703-5525Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Matthew J. McLeodiD· 1 shared Robert Edward ThorneiD· 1 shared Todd HolyoakiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBiophysics

Matthew J. McLeodORCID

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1 paper

Recent·Most cited

BiophysicsStructurePeer-reviewedMar 22, 2025

A structural perspective on the temperature-dependent activity of enzymes

Matthew J. McLeod, Sarah A. E. Barwell, Todd Holyoak, Robert Edward Thorne

The paper uses multi-temperature X-ray crystallography to show how temperature-dependent structural changes in enzyme complexes affect activity and challenge assumptions of Arrhenius/Eyring model parameters.

30 citationstop 1%

structural biologyexperimental assay

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