ImmunologyFrontiers in ImmunologyPeer-reviewed
Targeting PD-L1 in solid cancer with myeloid cells expressing a CAR-like immune receptor
Kayla Myers Chen, Daniel Grun, Brian Gautier…·Peter Andersen
This study demonstrates that engineered myeloid cells expressing a PD-1-based CAR-like receptor can recognize and attack PD-L1+ solid tumors, enhancing phagocytosis and slowing tumor growth in vivo.