Qing Hua Sun

Struct2SeQ uses deep Q-learning to design RNA sequences that fold into target structures and match SHAPE reactivity constraints, outperforming humans and existing methods.

This study identifies E. coli-derived vitamin B6 (PLP) as essential for resuming postembryonic development in C. elegans after developmental arrest.

The paper identifies E. coli purE mutants that delay C. elegans development and increase stress tolerance via DAF-16 nuclear translocation.

This paper programs animal physiology and behaviors using engineered bacteria that modulate gene expression, behavior, and metabolism in Caenorhabditis elegans through RNA interference.