Dual pathway regulation of castration response and ferroptosis in the prostate epithelium
Weiping Li, Jingbo Zhou, Zejian Wang, Fereshteh Zandkarimi, Teresa A. Milner, Shouhong Xuan, John R. Christin, Caroline J. Laplaca, Andrew S. Greenberg, John P. Chute, Hanina H. Hibshoosh, Brent R. Stockwell, Michael M. Shen
The paper shows that castration induces prostate epithelial regression via ferroptosis, mediated by two AR signaling pathways controlled by NKX3.1 and PTN.
bioRxiv · Aug 6, 2025 · PreprintDevelopmental Biology