Teresa A. Milner

Increased expression of developmental Nav1.3 promotes hippocampal CA3 hyperexcitability in early-stage 5xFAD mice

This study shows increased Nav1.3 expression in early-stage 5xFAD mice leads to CA3 hyperexcitability, suggesting Nav1.3 as a target for AD intervention.

Subcellular Localization of Dopamine D1 and D2 Receptors in the Mouse Hippocampus

The paper uses electron microscopic immunocytochemistry to map the subcellular localization of D1R and D2R in the mouse hippocampus, revealing distinct synaptic and non-synaptic distributions.

A Versatile AAV-TH-SNCA Model to Study Early α-Synuclein Pathology and Intervention

This paper develops an optimized AAV.TH.SNCA model to study early α-synuclein pathology in mice, showing that motor deficits and neurochemical changes occur before neuronal loss.

Fast-acting antidepressants trigger presynaptic BDNF release and structural plasticity at mouse mossy fiber-CA3 synapses

This study shows fast-acting antidepressants like ketamine trigger BDNF release from presynaptic terminals in mouse hippocampal neurons, leading to structural plasticity in CA3 pyramidal neurons.

Dual pathway regulation of castration response and ferroptosis in the prostate epithelium

The paper shows that castration induces prostate epithelial regression via ferroptosis, mediated by two AR signaling pathways controlled by NKX3.1 and PTN.

Perimenopause promotes neuroinflammation in select hippocampal regions in a mouse model of Alzheimers disease

This study shows that perimenopause increases Aβ aggregation and glial activation in specific hippocampal regions in female 5xFAD mice, but not cognitive deficits.

ScISOr-ATAC reveals convergent and divergent splicing and chromatin specificities between matched cell types across cortical regions, evolution, and in Alzheimer's disease.

The paper introduces ScISOr-ATAC to measure splicing and chromatin accessibility in frozen brain tissues, finding convergent and divergent patterns in different cell types and conditions.

Single-cell long-read mRNA isoform regulation is pervasive across mammalian brain regions, cell types, and development

The paper analyzes single-cell long-read mRNA isoform regulation across mouse brain regions, cell types, and development, finding pervasive isoform variability and cell-type specific splicing patterns.

BDNF induces its own release to mediate presynaptic plasticity

This paper shows BDNF induces its own release to mediate long-lasting increase in neurotransmitter release through TrkB and calcium-dependent mechanisms.

Single-nuclei isoform RNA sequencing reveals combination patterns of transcript elements across human brain cell types

The paper introduces SnISOr-Seq, a method for single-nuclei isoform RNA sequencing, and finds distinct combination patterns of transcript elements in human brain cell types.

Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain

This study characterizes the distribution and localization of PI5P4K and PI5P4Kβ in mouse and human brains, showing distinct expression patterns in different brain regions and cell types.