Brent R. Stockwell

Hydroperoxy-lipids Are Essential Yet Insufficient For Execution Of Ferroptosis

The paper shows that hydroperoxy-phospholipids are necessary but insufficient for ferroptosis, requiring additional Fe-catalyzed processes and agents to complete the death program.

All-Optical Multimodal Mapping of Single Cell Type-Specific Metabolic Activities via REDCAT

REDCAT maps single-cell type-specific metabolic activities in tissues using multimodal all-optical imaging, revealing metabolic specialization and reprogramming in immune and liver tissues.

LYNX: a deep generative model for linking spatial dynamics and cellinteractions in multimodal spatial data

LYNX is a deep generative model that integrates multimodal spatial data to model spatial dynamics and cell-cell interactions across tissues.

A Paracrine Dietary Lipid Axis Constrains Antitumor Immunity in Liver Cancer

This study identifies a dietary lipid axis driven by linoleic acid and FADS2 that suppresses antitumor immunity in liver cancer, offering a therapeutic target for immunotherapy resistance.

miR-940 suppresses ferroptosis by controlling expression of key regulatory genes

This study identifies miR-940 as a negative regulator of ferroptosis, showing it suppresses cell death by modulating key genes and GPX4 levels in cancer cells.

IDH-mutant inhibitors enhance the sensitivity of IDH1-mutant gliomas to cysteine-methionine deprivation and ferroptosis

This study shows that IDH1-mutant glioma cells are more sensitive to cysteine-methionine deprivation and ferroptosis inducers, and that IDH inhibitors enhance this sensitivity.

Dual pathway regulation of castration response and ferroptosis in the prostate epithelium

The paper shows that castration induces prostate epithelial regression via ferroptosis, mediated by two AR signaling pathways controlled by NKX3.1 and PTN.

LIMD1 Loss Confers a GPX4-Dependent Cell State in Lung Cancer

This study identifies GPX4 as a therapeutic target in LIMD1-deficient lung cancer by showing its role in ferroptosis susceptibility.

Ferroptosis regulates hemolysis in stored murine and human red blood cells

This study identifies Steap3 as a regulator of ferroptosis-like lipid peroxidation in stored RBCs, linking genetic variants to hemolysis in mice and human blood donors.

Compound Mechanism of Action and Polypharmacology can be Elucidated by Large-Scale Perturbational Profile Analysis

The paper uses large-scale perturbation profiles to analyze drug mechanisms of action and polypharmacology across multiple tumor subtypes and tissues.