Chemotherapy-induced transfer of apoptotic machinery in extracellular vesicles between somatic and germ cells of the testis: mechanistic insights into onco-fertility preservation in pre-pubertal boys
Michael P. Rimmer, Pamela J. Holland, Daniel Rabe, Shannon L. Stott, Christopher D. Gregory, Rod Mitchell
This study investigates how chemotherapy-induced extracellular vesicles from Sertoli cells affect apoptosis in somatic and germ cells of the testis, revealing dual roles in promoting somatic cell death and protecting germ cells.
bioRxiv · Jan 20, 2026 · PreprintCell Biology