Intrinsically disordered regions navigate DNA replication licensing factors to specific genomic loci.
Innesa Leonovich, Matthew W. Parker
bioRxiv · Sep 17, 2026 · PreprintCell Biology
Author
Matthew W. Parker
The University of Texas Southwestern Medical CenterORCID 0000-0002-7571-0010Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2023-2026 · peak 2/yrCo-Author Collaboration Network
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Phosphorylation alters the bulk chemical properties of Orc1 to tune DNA binding, phase separation, and heterochromatin partitioning
Olubu A Adiji, Innesa Leonovich, Matthew W. Parker
This study shows phosphorylation of Orc1 IDR modulates DNA binding, phase separation, and heterochromatin recruitment in Drosophila.
bioRxiv · Aug 20, 2026 · PreprintBiochemistry
Protein intrinsically disordered regions have a non-random, modular architecture
Brendan S. McConnell, Matthew W. Parker
The paper develops a statistical method to analyze amino acid composition variance in disordered protein regions, revealing modular, non-random organization.
Bioinformatics · Dec 1, 2023Peer-reviewedBioinformatics