Combining Directed Evolution with Machine Learning Enables Accurate Genotype-to-Phenotype Predictions
Alexander J. Howard, Ellen Youngsoo Rim, Oscar D. Garrett, Yejin Shim, James H. Notwell, Pamela C. Ronald
The paper combines directed evolution with a protein language model to predict genotype-to-phenotype relationships in rice immune receptors, identifying variants with improved ligand binding.
bioRxiv · Jan 27, 2025 · PreprintBioinformatics