Haruna B. Choijilsuren

This study shows chronic alcohol exposure leads to inflammation, DNA damage, and transposon activation in hematopoietic stem and progenitor cells, with lasting effects on myeloid bias and immune responses.

The paper identifies ALDH9A1 deficiency as a source of endogenous DNA damage that requires FA pathway repair, leading to genomic instability and tumorigenesis in FA-deficient cells.