Jörg Isensee

The paper develops a mechanistic model of PKA dynamics in nociceptive neurons to quantify how pro- and anti-nociceptive inputs shape its activity and provides testable predictions for opioid modulation.

The paper analyzes transcriptome data to show Cdkn1a but not Cdkn2a is upregulated in DRG neurons across neuropathic pain models.

This paper investigates Cav1.2-dependent excitation-transcription coupling in nociceptors, showing it modulates pain sensitivity by affecting gene expression and neuronal function.

This study shows that autophagy regulates neuronal excitability by controlling cAMP/PKA signaling through the targeting of PKA inhibitory subunits to autophagosomes.

This paper shows anthrax toxin can target and modulate pain by acting on nociceptive neurons through ANTXR2, with potential for new pain therapeutics.