Tim B. Hucho

Suzetrigine-evoked analgesia is potentiated by Nav1.7 null-related opioid mechanisms.

The paper investigates how Nav1.7 loss enhances opioid signaling and analgesia, showing that suzetrigine-evoked analgesia is potentiated by RGS antagonists and low-dose morphine in inflammatory pain models.

A mechanistic model of protein kinase A dynamics under pro- and anti-nociceptive inputs

The paper develops a mechanistic model of PKA dynamics in nociceptive neurons to quantify how pro- and anti-nociceptive inputs shape its activity and provides testable predictions for opioid modulation.

Senescence-associated Cdkn1a (p21) is upregulated in rodent dorsal root ganglion neurons across lesion-based neuropathic pain models

The paper analyzes transcriptome data to show Cdkn1a but not Cdkn2a is upregulated in DRG neurons across neuropathic pain models.

CaV1.2-dependent excitation-transcription coupling modulates nociception

This paper investigates Cav1.2-dependent excitation-transcription coupling in nociceptors, showing it modulates pain sensitivity by affecting gene expression and neuronal function.

Autophagy regulates neuronal excitability by controlling cAMP/Protein Kinase A signaling

This study shows that autophagy regulates neuronal excitability by controlling cAMP/PKA signaling through the targeting of PKA inhibitory subunits to autophagosomes.

Anthrax Toxin as a Molecular Platform to Target Nociceptive Neurons and Modulate Pain

This paper shows anthrax toxin can target and modulate pain by acting on nociceptive neurons through ANTXR2, with potential for new pain therapeutics.

Mechanistic hierarchical population model identifies latent causes of cell-to-cell variability

This study introduces a hierarchical population model to identify latent causes of cell-to-cell variability in heterogeneous populations using single-cell data.