Seth D Temple

This paper proposes a method to correct for multiple testing in IBD mapping for case-control studies, identifies six genome-wide significant AD risk loci, and shows positive selection can confound results.

This study examines how SARS-CoV-2 evolved to escape 1,603 antibodies by analyzing mutation dynamics and selective pressures over 3.5 years of the pandemic.

FLARE2 improves local ancestry inference by using haplotype clustering, enabling accurate results even when reference panels are poorly matched.

The paper proposes a method to correct for multiple testing in genome scans for recent positive selection using identity-by-descent segments, showing it controls FWER and detects selection signals across ancestry groups.

The paper shows that the detectable identity-by-descent rate is asymptotically normal and generalizes this result to complex demographic scenarios and multi-way segments.

The paper estimates mutation rates across SARS-CoV-2 genome sites and identifies factors influencing these rates, finding significant variability and patterns related to gene boundaries, sequence context, and RNA structure.

This paper introduces an efficient algorithm for simulating identity-by-descent segments, achieving linear scaling in sample size and enabling feasible statistical analyses of large datasets.

This paper develops statistical methods to detect and estimate recent positive selection in European ancestry populations using identity-by-descent haplotype segments.