Marina Grisoli

Brain digital twins reveal network changes in congenital and slowly progressive cerebellar ataxias

This study uses brain digital twins to compare network changes in congenital and slowly progressive cerebellar ataxias, finding distinct patterns in network topology and dynamics that correlate with clinical symptoms.

The Pattern and Staging of Brain Atrophy in Spinocerebellar Ataxia Type 2 (SCA2): MRI Volumetrics from ENIGMA-Ataxia

This study uses MRI volumetrics to characterize brain atrophy patterns in SCA2, finding progressive degeneration starting in cerebellar white matter and spreading to other brain regions.

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

This paper introduces SuStaIn, a machine learning method that identifies disease subtypes and their temporal progression from cross-sectional data, improving prediction of diagnostic conversion in neurodegenerative diseases.