CRISPR screen for rAAV production implicates genes associated with infection
E. O'Driscoll, Sakshi Arora, Jonathan F. Lang, Beverly L. Davidson, Ophir Shalem
The paper uses a CRISPR screen to identify genes affecting rAAV production in HEK 293 cells, finding that heparan sulfate biosynthesis and vesicular trafficking genes influence yield.
Molecular Therapy — Methods & Clinical Development · Jan 18, 2025Peer-reviewedCell Biology