Author

Sakshi Arora

Children's Hospital of PhiladelphiaORCID 0000-0002-4347-480XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Beverly L. DavidsoniD· 2 shared Benjamin L. ProsseriD· 1 shared Deborah L. FrenchiD· 1 shared E. O'Driscoll· 1 shared Elisa A. WaxmaniD· 1 shared Elizabeth A. HelleriD· 1 shared Giulia PavaniiD· 1 shared Ingie HongiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Beverly L. DavidsonORCID

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2 papers

Recent·Most cited

CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy for SYNGAP1-related intellectual disability

Laura Sichlinger, Molly B. Reilly, Sakshi Arora, Shuo Zhang, Nicolas Marotta, Kiara L. Rodríguez-Acevedo, Marisol Hooks, Kyle S. Czarnecki, Julia J. Winter, Elisa A. Waxman, Lea V. Dungan, Ingie Hong, Yoichi Araki, Richard C. Johnson, Richard L. Huganir, , Elizabeth A. Heller

This paper demonstrates that CRISPR-mediated transcriptional activation can upregulate SYNGAP1 in a mouse model of SRID and human neurons, rescuing deficits without targeting mutations.

bioRxiv · Oct 28, 2025 · PreprintNeuroscience

CRISPR screen for rAAV production implicates genes associated with infection

E. O'Driscoll, Sakshi Arora, Jonathan F. Lang, Beverly L. Davidson, Ophir Shalem

The paper uses a CRISPR screen to identify genes affecting rAAV production in HEK 293 cells, finding that heparan sulfate biosynthesis and vesicular trafficking genes influence yield.

Molecular Therapy — Methods & Clinical Development · Jan 18, 2025Peer-reviewedCell Biology