Bone Marrow Spatial Transcriptomics Reveals a Myeloma Cell Architecture with Dysfunctional T-Cell Distribution, Neutrophil Traps, and Inflammatory Signaling
Emma Muiños-López, Ana Rosa López-Pérez, Laura Sudupe, Amaia Vilas‐Zornoza, Sarai Sarvide, Purificación Ripalda‐Cemboráin, Paula Aguirre‐Ruiz, Patxi San Martín‐Úriz, Marta Larráyoz, Laura Álvarez-Gigli, Marta Abengozar‐Muela, Itziar Cenzano, Miguel Cócera, Javier Ruiz, Ignacio Sancho, , Felipe Prósper
This study uses spatial transcriptomics to analyze bone marrow in MM mouse models and patients, revealing altered T-cell distribution, neutrophil traps, and inflammatory signaling in MM.
Communications Biology · Nov 20, 2025Peer-reviewedCancer Biology