Borja Sáez

This study identifies transcriptional changes in stromal and endothelial cells during MGUS to myeloma progression and treatment response, revealing a tumor-permissive BME signature that is modulated by therapy.

This study shows clonal hematopoiesis promotes fibrosis by altering macrophage behavior and tissue repair processes in lung disease.

This study uses spatial transcriptomics to analyze bone marrow in MM mouse models and patients, revealing altered T-cell distribution, neutrophil traps, and inflammatory signaling in MM.

This study shows that airway basal stem cells maintain intraepithelial airway macrophages via Notch signaling, enabling localized allergic inflammation in the trachea but not distal lung tissues.

This study identifies novel RAB13+ endothelial and profibrotic mesenchymal cells in aged human bone marrow using single-cell RNA sequencing and spatial transcriptomics.

This study uses CRISPR screens and Perturb-Seq to analyze 550 chromatin factors in haematopoiesis and AML, revealing lineage-specific roles and therapeutic implications.