Myelin dystrophy in the aging prefrontal cortex leads to impaired signal transmission and working memory decline: a multiscale computational study
Sara Ibañez, Nilapratim Sengupta, Jennifer Irene Luebke, Klaus Wimmer, Christina M. Weaver
This study uses computational models to show that age-related myelin dystrophy in the prefrontal cortex impairs working memory by reducing conduction velocity and increasing action potential failures.
eLife · Oct 31, 2023Peer-reviewedNeuroscience