Pharmacology & ToxicologybioRxivPreprint
Systemic CYP3A inhibition by ritonavir enables selective targeting of hypoxic tumour cells by prodrugs of DNA-PK inhibitors
Cho Rong Hong, Benjamin D. Dickson, Lydia P. Liew…·Michael P. Hay
This paper shows that ritonavir enhances the hypoxia-targeted delivery of DNA-PK inhibitors, improving radiosensitization of tumors while sparing normal tissue.
DOI 10.64898/2026.02.12.705643