Systemic CYP3A inhibition by ritonavir enables selective targeting of hypoxic tumour cells by prodrugs of DNA-PK inhibitors
Cho Rong Hong, Benjamin D. Dickson, Lydia P. Liew, Way Wua Wong, Jagdish Kumar Jaiswal, Stephen M. F. Jamieson, Jacqueline Ross, Longjin Zhong, David M. Shackleford, William Robert Wilson, Michael P. Hay
This paper shows that ritonavir enhances the hypoxia-targeted delivery of DNA-PK inhibitors, improving radiosensitization of tumors while sparing normal tissue.
bioRxiv · Feb 14, 2026 · PreprintPharmacology & Toxicology