Paul D. Smolen

Long-term dynamic profiles of cognitive kinases induced by different learning protocols

The paper examines the long-term dynamics of cognitive kinases in response to different learning protocols in Aplysia, finding distinct activation patterns and molecular interactions.

Enhancing associative learning in rats with a computationally designed training protocol

This study shows that a computationally designed training protocol with irregular intervals enhances associative learning in rats by improving fear memory retrieval and extinction.

MeCP2 represses the induction and maintenance of long-term synaptic plasticity

This study investigates MeCP2's role in long-term synaptic plasticity using Aplysia sensorimotor synapses, finding it inhibits gene expression needed for plasticity formation and maintenance.

Dynamics and mechanisms of ERK activation after different protocols that induce long-term facilitation in Aplysia

The paper investigates ERK activation dynamics after different LTF-inducing protocols in Aplysia and finds that the Enhanced protocol leads to prolonged ERK activity compared to others.

Computational analysis of memory consolidation following inhibitory avoidance (IA) training in adult and infant rats: critical roles of CaMKIIα and MeCP2

The paper develops a computational model to study memory consolidation dynamics in adult and infant rats, revealing critical roles of CaMKIIα and MeCP2 in memory stability and forgetting.

Defective synaptic plasticity in a model of Coffin-Lowry Syndrome is rescued by simultaneously targeting PKA and MAPK pathways

The paper shows that combining PKA and MAPK pathway activators rescues synaptic plasticity deficits in a CLS model by synergistically restoring RSK phosphorylation and LTF.

Comparing Theories for the Maintenance of Late LTP and Long-Term Memory: Computational Analysis of the Roles of Kinase Feedback Pathways and Synaptic Reactivation

The paper uses computational models to compare kinase feedback pathways and synaptic reactivation in maintaining long-term memory and LTP.