SPARP-seq reveals poly(A) tail shortening as a hallmark of the active human translatome
Shu Yi, Juzuo Li, Zhiyuan Sun, Yanping Li, Wenqin Lu, Yanping Long, Xi Chen, Sisi Li, Wei Chen, Jixian Zhai
The paper introduces SPARP-seq, a method combining poly(A) assessment and ribosome profiling to show poly(A) tail shortening is a hallmark of active translation in human cells.
bioRxiv · Nov 25, 2025 · PreprintMolecular Biology