Effective lowering of α-synuclein expression by targeting G-quadruplex structures within the SNCA gene
Valentina Pirota, Federica Rey, Letizia Esposito, Valentina Fantini, Cecilia Pandini, Erika Maghraby, Rosalinda Di Gerlando, Filippo Doria, Mariella Mella, Orietta Pansarasa, Paolo Gandellini, Mauro Freccero, Stephana Carelli, Cristina Cereda
This study identifies G-quadruplex structures in the SNCA gene and demonstrates their modulation using ligands and peptide nucleic acids to lower alpha-synuclein expression.
International Journal of Biological Macromolecules · Aug 2, 2024Peer-reviewedMolecular Biology