Orietta Pansarasa

DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue.

This study shows that TDP-43 and FUS cytoplasmic inclusions impair DNA damage response and repair, and that pharmacological stimulation of DDR can rescue these defects in ALS models.

Effective lowering of α-synuclein expression by targeting G-quadruplex structures within the SNCA gene

This study identifies G-quadruplex structures in the SNCA gene and demonstrates their modulation using ligands and peptide nucleic acids to lower alpha-synuclein expression.

Different RNA profiles in plasma derived small and large extracellular vesicles of Neurodegenerative diseases patients.

The paper compares RNA profiles in plasma-derived large and small extracellular vesicles from neurodegenerative disease patients and healthy controls, identifying disease-specific miRNA signatures.