Leandro Matías Sommese

Functional Specialization of Ca2+ - Binding Motifs in Human MICU1

This paper identifies a novel Ca2+-binding motif in MICU1 that functions as an early sensor, triggering structural changes that refine its regulatory role in mitochondrial Ca2+ uptake.

Structural and evolutionary analysis unveil functional adaptations in the promiscuous behavior of serum albumins

The paper identifies a conserved promiscuous reaction in serum albumins across mammals and suggests evolutionary adaptations in residues with unknown functions.

CardIAP: Calcium images analyzer web application

CardIAP is a web application that automates the analysis of calcium fluorescence imaging data to identify spatio-temporal patterns and extract quantitative information on calcium dynamics.

ProtMiscuity: a database of promiscuous proteins

ProtMiscuity is a manually-curated database of promiscuous proteins containing 57 proteins from 40 organisms with 88 reactions, providing annotated data linked to other resources.