Selective depletion of cancer cells with extrachromosomal DNA via lentiviral infection
Eunhee S. Yi, Amit D. Gujar, Dacheng Zhao, Kentaro Suina, Xue Jin, Katharina Pardon, Qinghao Yu, Larisa Kagermazova, Emmanuel Ekow Korsah, Noah A. Dusseau, Jef D. Boeke, Anton George Henssen, Roel G.W. Verhaak
The paper observes that lentiviral infection selectively depletes cells containing extrachromosomal DNA (ecDNA), suggesting potential therapeutic strategies for ecDNA-driven cancers.
Cancer Research Communications · Aug 1, 2025Peer-reviewedCancer Biology