Author

Peter C. Ruben

Simon Fraser UniversityORCID 0000-0002-7877-5178Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Assay:electronic health records· 1 Organism:human· 1 Approach:mixed model· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew Michael GlazeriD· 1 shared Ayesha MuhammadiD· 1 shared Bian LiiD· 1 shared Dan M. RodeniD· 1 shared Dana A. PageiD· 1 shared Matthew J. O’NeilliD· 1 shared Megan Cummins LancasteriD· 1 shared Michael John AckermaniD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperGenetics

Andrew Michael GlazerORCID

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1 paper

Recent·Most cited

Multifocal Ectopic Purkinje Premature Contractions due to neutralization of an SCN5A negative charge: structural insights into the gating pore hypothesis

Andrew Michael Glazer, Tao Yang, Bian Li, Dana A. Page, Mohamed A. Fouda, Yuko Wada, Megan Cummins Lancaster, Matthew J. O’Neill, Ayesha Muhammad, Xiaozhi Gao, Michael John Ackerman, Shubhayan Sanatani, Peter C. Ruben, Dan M. Roden

The paper identifies a novel SCN5A variant, E171Q, that creates a gating pore current by neutralizing a negative charge in the S2 helix, leading to MEPPC and altered voltage dependence.

bioRxiv · Feb 13, 2024 · PreprintGenetics