Author

Tao Yang

Vanderbilt University Medical CenterORCID 0000-0002-1127-9364Unclaimed ORCID profile · follow to get notified of new preprints

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Tao Yang10 papers · BGI Research

Biology Disciplines

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Genetic & Genomic Medicine· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:variant effect prediction· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Assay:electronic health records· 1 Approach:mixed model· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew Michael GlazeriD· 3 shared Dan M. RodeniD· 3 shared Ayesha MuhammadiD· 2 shared M. Lorena HarveyiD· 2 shared Maria E. CalandranisiD· 2 shared Matthew J. O’NeilliD· 2 shared Megan Cummins LancasteriD· 2 shared Bian LiiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Andrew Michael GlazerORCID

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3 papers

Recent·Most cited

Mapping the Functional Landscape of KCNQ1 to Define Ion Channel Mechanisms and Arrhythmia Risk

M. Lorena Harvey, Ellen M Osborn, Megan Cummins Lancaster, Joseh J. Smith, Qianyi Shen, Temidayo Abe, Ruoyi Cai, Ayesha Muhammad, Rose Kannankeril, Tao Yang, Maria E. Calandranis, Daniel J. Blackwell, Richard E Dolder, Jessa L. Aldridge, Matthew R. Fleming, , Andrew Michael Glazer

The paper maps the functional landscape of KCNQ1 variants to identify pathogenic and benign variants, revealing their impact on arrhythmia risk and ion channel mechanisms.

medRxiv · Dec 16, 2025 · PreprintGenetic & Genomic Medicine

ParSE-seq: A Calibrated Multiplexed Assay to Facilitate the Clinical Classification of Putative Splice-altering Variants

Matthew J. O’Neill, Tao Yang, Julie A. Laudeman, Maria E. Calandranis, M. Lorena Harvey, Joseph F. Solus, Dan M. Roden, Andrew Michael Glazer

This paper introduces ParSE-seq, a multiplexed assay to assess splice-altering variants, showing high correlation between experimental and computational predictions.

Nature Communications · Sep 27, 2024Peer-reviewedGenetic & Genomic Medicine

Multifocal Ectopic Purkinje Premature Contractions due to neutralization of an SCN5A negative charge: structural insights into the gating pore hypothesis

Andrew Michael Glazer, Tao Yang, Bian Li, Dana A. Page, Mohamed A. Fouda, Yuko Wada, Megan Cummins Lancaster, Matthew J. O’Neill, Ayesha Muhammad, Xiaozhi Gao, Michael John Ackerman, Shubhayan Sanatani, Peter C. Ruben, Dan M. Roden

The paper identifies a novel SCN5A variant, E171Q, that creates a gating pore current by neutralizing a negative charge in the S2 helix, leading to MEPPC and altered voltage dependence.

bioRxiv · Feb 13, 2024 · PreprintGenetics