Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter
Victor Hugo Pérez Carrillo, Margot Di Cesare, Dania Rose-Sperling, Waqas Javed, Hannes Neuweiler, Julien Marcoux, Cédric Orelle, Jean‐Michel Jault, Ute A. Hellmich
The paper identifies a conserved residue cluster in BmrA that mediates communication between nucleotide and substrate binding sites in type IV ABC transporters through coupling helix 2.
Nature Communications · Nov 11, 2025Peer-reviewedBiophysics