Julien Marcoux

The paper analyzes translatome and translation dynamics in RiboCancer cell lines to show that Rps15 mutations disrupt tRNA accommodation, affecting translation efficiency and transcriptional regulation in CLL.

This study uses an in vitro reconstitution system to show that IFT proteins enhance HSET kinesin processivity, promoting microtubule sliding and centrosome clustering.

The paper uses cryo-EM and simulations to reveal how LptM and LptY facilitate LPS transport by modulating LptD conformational dynamics in the translocon complex.

This study identifies ribosome biogenesis as a therapeutic vulnerability in TNBC, showing that inhibiting rRNA maturation via Fibrillarin or RNA Pol I reduces tumor growth without significant cell death.

The paper identifies a conserved residue cluster in BmrA that mediates communication between nucleotide and substrate binding sites in type IV ABC transporters through coupling helix 2.

This study identifies the mechanism by which Kip2 promotes microtubule growth through a bipartite polymerase module that delivers tubulin to microtubule plus-ends.

This study identifies effluxosomes as dynamic membrane structures in M. tuberculosis that coordinate multi-metal resistance through PacL proteins and P-ATPase pumps.

This paper reveals structural and functional differences in PA200 interaction with the immunoproteasome (i20S) compared to the standard proteasome (s20S), showing PA200 enhances i20S activation and regulates its gene expression.

The paper identifies SURF2 as a MDM2 antagonist that modulates nucleolar stress responses by buffering free-5S RNP particles, linking it to cancer resistance and patient survival.

This study identifies LRP1 N-glycans with terminal galactoses as ligands for DCIR, revealing its specificity in immune regulation and potential therapeutic applications.

The paper identifies a dual key lock mechanism involving RIO1 and RPS26 that controls the final maturation step of 40S ribosomal subunits by displacing DIM2 and enabling NOB1-mediated cleavage of 18S rRNA.