Alejandra Medina-Rivera

The paper identifies transcriptional disruptions in dendritic cells from SLE patients, highlighting interferon-driven changes, impaired IL-10 signaling, and altered lipid metabolism as key factors in tolerance dysfunction.

This study evaluates polygenic risk scores for Parkinson's disease in admixed Latin American populations, finding that European-derived PRS outperform ancestry-matched but underpowered datasets.

The paper builds a logical model of IL10-driven tolerogenic dendritic cells (tolDC) using gene expression and literature, showing key transcription factors are essential for tolDC stability.

This study estimates the genetic contribution to astigmatism and myopia in the Mexican population using twin data and finds high heritability and genetic correlations.

PulmonDB provides a curated database and R library for exploring gene expression in COPD and IPF, enabling differential expression analysis and hypothesis generation.

The paper introduces Var-tools, a framework for predicting the impact of regulatory variants on transcription factor binding, with four case studies demonstrating its functionality.