The paper identifies speech-related neural activity in IDH-mutant gliomas using electrocorticography, showing task-based and resting-state distinctions that could improve surgical outcomes.

bioRxiv · Jul 4, 2025 · PreprintNeuroscience

Aperiodic neural dynamics define a novel signature of glioma-induced excitation-inhibition dysregulation

Youssef Sibih, Abraham O Dada, Emily E Cunningham, Niels Olshausen, Jasleen Kaur, Jayabal Velmurugan, Sena Oten, Sanjeev J. Herr, Cesar Nava Gonzales, Andy G. S. Daniel, Saritha Krishna, Vardhaan Sai Ambati, Alexander A. Aabedi, Gray S. Umbach, Kanish Mirchia, , Shawn L. Hervey‐Jumper

The paper investigates how glioma infiltration affects the aperiodic slope of neural dynamics, finding it correlates with excitation dominance and semantic naming impairments.

bioRxiv · May 23, 2025 · PreprintCancer Biology

Functional alterations in cortical processing of speech in glioma-infiltrated cortex

Alexander A. Aabedi, Benjamin Lipkin, Jasleen Kaur, Sofia Kakaizada, Claudia Valdivia, Sheantel J. Reihl, Jacob S. Young, Anthony T. Lee, Saritha Krishna, Mitchel Stuart Berger, Edward F. Chang, David Brang, Shawn L. Hervey‐Jumper

This study investigates how glioma-infiltrated cortex participates in speech processing by comparing neural activity with normal-appearing cortex using electrocorticography.

Proceedings of the National Academy of Sciences · Nov 9, 2021Peer-reviewedNeuroscience

Convergence of Heteromodal Lexical Retrieval in the Lateral Prefrontal Cortex

Alexander A. Aabedi, Sofia Kakaizada, Jacob S. Young, Jasleen Kaur, Olivia Wiese, Claudia Valdivia, Saritha Krishna, Christina Weyer Jamora, Mitchel Stuart Berger, Daniel H. Weissman, David Brang, Shawn L. Hervey‐Jumper

This study uses lesion-symptom mapping in patients with aphasia to show that visual and auditory lexical retrieval tasks share overlapping neural systems in the left lateral prefrontal cortex.

Scientific Reports · Mar 18, 2021Peer-reviewedNeuroscience