Early Metabolic Alterations in Cerebrospinal Fluid Fatty Acid Profiles Linked to Cognitive Decline and All-Cause Dementia
Jacob Apibilla Ayembilla, Yannick N. Wadop, Rebecca Bernal, Biniyam Alemayehu Ayele, Muralidharan Sargurupremraj, Xueqiu Jian, Alfred Kongnyu NJAMNSHI, Sudha S. Seshadri, Alice B. S. Nono Djotsa, Jayandra Jung Himali, Bernard Fongang, Alfred Nji Fonteh
This study identifies CSF fatty acid profiles as better predictors of cognitive decline than traditional biomarkers like Aβ42 and tau, suggesting early metabolic changes in dementia.
bioRxiv · Aug 25, 2025 · PreprintNeuroscience