Bernard Fongang

Nanopore Long-Read Sequencing Unveils Genomic Disruptions in Alzheimer's Disease

This study uses nanopore long-read sequencing to analyze genomic disruptions in Alzheimer's disease, finding increased retrotransposon activity and structural variants in aged brains.

Differential Patterns of Gut and Oral Microbiomes in Hispanic Individuals with Cognitive Impairment

This study examines oral and gut microbiome differences in Hispanic individuals with and without cognitive impairment, finding oral microbiome changes but no synergistic effects with gut microbiomes in ADRD.

Altered Gut Microbiota Mediates the Association between APOE Genotype and Amyloid-β Accumulation in Middle-Aged Adults

This study shows that gut microbiota mediates the effect of APOE ε4 genotype on amyloid-β accumulation in middle-aged adults.

Early Metabolic Alterations in Cerebrospinal Fluid Fatty Acid Profiles Linked to Cognitive Decline and All-Cause Dementia

This study identifies CSF fatty acid profiles as better predictors of cognitive decline than traditional biomarkers like Aβ42 and tau, suggesting early metabolic changes in dementia.

Adherence to Lifes Essential 8 Enhances Gut Microbiota Diversity and Cognitive Performance

This study shows that better adherence to LE8 metrics improves gut microbiota diversity and cognitive performance in the Framingham Heart Study participants.

Quinolinic acid links kidney injury to brain toxicity

This study identifies quinolinic acid as a key metabolite linking kidney injury to brain toxicity through the kynurenine pathway in mice and humans.

Cerebral Small Vessel Disease Burden is Associated with Decreased Abundance of Gut Barnesiella intestinihominis Bacterium in the Framingham Heart Study

The paper investigates the relationship between gut microbiota and cerebral small vessel disease markers in the Framingham Heart Study, finding associations between specific bacterial genera and cSVD burden.

A meta-analysis of genome-wide association studies identifies new genetic loci associated with all-cause and vascular dementia

This study performs a meta-analysis of GWAS to identify new genetic loci associated with all-cause and vascular dementia, revealing shared and distinct risk factors.

Analyzing and interpreting DNA double-strand break sequencing data

The paper introduces iSeq, a tool for analyzing DSB-sequencing data, enabling identification and annotation of DSB-enriched regions across various resolutions.

Co-evolutionary analysis accurately predicts details of interactions between the Integrator complex subunits

The paper modifies Direct Coupling Analysis to predict interaction domains in large protein complexes, validated on known and unknown complexes.

Protein Co-Evolution Strategies Detect Predicted Functional Interaction Between the Serotonin 5-HT2A and 5-HT2C Receptors

The paper identifies functional interactions between 5-HT2A and 5-HT2C receptors using coevolution analysis and finds significant correlations between predicted binding interfaces and SNPs in these proteins.

qDSB-Seq: quantitative DNA double-strand break sequencing

qDSB-Seq quantifies absolute DNA double-strand break frequencies and their genomic coordinates across samples and organisms.

Integrated analysis of patterns of DNA breaks reveals break formation mechanisms and their population distribution during replication stress

The High-resolution Timeline of Expression of Ribosomal Protein Genes in Yeast

The paper estimates the high-resolution timeline of ribosomal protein gene expression in yeast, showing a 25-minute sequence with genes for mature ribosome proteins expressed later than others involved in biogenesis.