Alexander Gusev

The paper integrates gene expression and GWAS data to identify novel genes associated with obesity-related traits.

The paper shows that haplotypes of common SNPs explain more heritability of complex diseases than individual SNPs alone.

The paper quantifies human mutation and gene conversion rates using IBD segments and population history, finding higher mutation rates than pedigree-based estimates but lower than primate substitution rates.

The paper analyzes the genetic architecture of schizophrenia and nine complex diseases using a fast variance components analysis, finding polygenic patterns and significant genetic correlations.

The paper introduces a new mixed model method for case-control studies that improves association power while controlling false positives, showing gains in power on real and simulated data.

The paper shows regulatory variants explain significantly more heritability than coding variants for 11 diseases, using imputed data across 218 cell types.