Glutamate and γ-aminobutyric acid differentially modulate glymphatic clearance of amyloid β through pulsation- and aquaporin-4 dependent mechanisms
Cheng Wu, Yiwei Feng, Qun Zhang, Fengyin Liang, Yue Lan, Zhong Pei, Guang-qing Xu
This study shows that glutamate and GABA modulate glymphatic clearance of amyloid β through distinct mechanisms involving pulsation and AQP4, with potential therapeutic implications for Alzheimer's disease.
bioRxiv · Jan 31, 2020 · PreprintNeuroscience